ARA-290

Product Overview

A fundamental standard in neurological and tissue protection research dictates that exploring advanced non-erythropoietic ligands requires complete structural integrity and verified chemical purity. The ARA-290 formulation addresses these demanding benchmarks, serving as a highly purified synthetic peptide developed for precise in vitro and in vivo laboratory modeling. Each vial provides pure ARA-290, stabilized as a vacuum freeze-dried (lyophilized) powder maintaining a verified purity profile of greater than 98%.

ARA-290 (also known as Cibinetide) is a synthetic 11-amino acid linear peptide derived from the three-dimensional structure of the B-helix of erythropoietin (EPO). It features the specific primary sequence H-Glx-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (often characterized as Pyr-Glu-Gln-Glu-Arg-Ala-Leu-Asn-Ser-Ser). Unlike native erythropoietin, which interacts heavily with homodimeric EPO receptors to drive red blood cell production, ARA-290 is engineered to lack erythropoietic activity completely. Its low molecular weight structural framework allows it to interact rapidly at the cellular level with high specificity, bypassing the complex clearance mechanisms associated with larger glycoproteins.

Operating as a selective tissue-protective agent, ARA-290 binds specifically to the Innate Repair Receptor (IRR), a heterocomplex composed of erythropoietin receptor subunits and the common beta subunit (CD131). The Innate Repair Receptor is typically up-regulated on cell surfaces following tissue injury, metabolic stress, or inflammatory signaling. Upon binding to the IRR, ARA-290 triggers intracellular survival cascades that inhibit pro-inflammatory cytokine pathways, attenuate oxidative stress, and halt apoptotic cellular death. Documented research demonstrates that ARA-290 actively supports the preservation and repair of small nerve fibers, protects vascular endothelial structures, and mitigates tissue damage in ischemic modeling. These distinct mechanisms allow for the precise investigation of peripheral neuropathy, chronic inflammatory pathways, and cellular cytoprotection within controlled laboratory settings.

Product Specifications

• Form: Lyophilized (vacuum freeze-dried) powder
• Purity: Greater than 98% (verified by HPLC analysis)
• Peptide Architecture: 11-amino acid linear chain (EPO B-helix derivative)
• Primary Target: Innate Repair Receptor (IRR / EPOR-CD131 heterocomplex)
• Primary Research Focus: Small Fiber Neuropathy Repair, Anti-Inflammatory Signaling, and Cytoprotection

Container Specifications

The physical attributes of the storage vessel directly impact the shelf life of the compound. All research environments should utilize clean, chemically inert containers. Glass vials provide the highest level of protection against gas permeability and chemical interaction, though high-density polypropylene tubes serve as a valid alternative. Keep all stored peptides away from automatic frost-free freezers, as their internal defrost cycles create regular temperature swings that compromise peptide longevity.