FOX04-DRI

Product Overview

A fundamental standard in cellular aging and senescence research dictates that exploring advanced targeted apoptotic agents requires complete structural integrity and verified chemical purity. The FOXO4-DRI formulation addresses these demanding benchmarks, serving as a highly purified synthetic peptide antagonist developed for precise in vitro and in vivo laboratory modeling of selective senolysis. Each vial provides pure FOXO4-DRI, stabilized as a vacuum freeze-dried (lyophilized) powder maintaining a verified purity profile of greater than 98%.

FOXO4-DRI (Forkhead box O4-D-Retro-Inverso) is a specially engineered 49-amino acid peptide designed to disrupt the endogenous interaction between the FOXO4 transcription factor and the p53 tumor suppressor protein. The peptide is synthesized entirely using D-amino acids in a reversed sequence order compared to the natural L-form peptide. This D-Retro-Inverso modification is a significant structural asset; it preserves the precise side-chain topology required for high-affinity target interaction while providing exceptional resistance to enzymatic cleavage and proteolytic breakdown within experimental mediums.

Operating primarily as a targeted senolytic signaling molecule, FOXO4-DRI specifically targets senescent cells exhibiting the senescence-associated secretory phenotype (SASP). In these cells, native FOXO4 binds to p53, keeping it sequestered in the nucleus and preventing it from inducing apoptosis. By competitively binding to the active site, FOXO4-DRI disrupts this complex, allowing p53 to translocate to the mitochondria and trigger the internal apoptotic cascade. Documented research demonstrates that this mechanism causes selective cell death in senescent populations while leaving healthy, proliferating cells unaffected. This provides researchers with a highly sophisticated model for investigating cellular rejuvenation, tissue homeostasis, and age-related physiological decline within controlled environments.

Product Specifications

• Form: Lyophilized (vacuum freeze-dried) powder
• Purity: Greater than 98% (verified by HPLC analysis)
• Peptide Architecture: D-Retro-Inverso (49-amino acid sequence consisting of D-enantiomers)
• Primary Target: FOXO4-p53 Intercellular Interaction
• Primary Research Focus: Selective Senolysis, Apoptotic Translocation, and Cellular Longevity

Container Specifications

The physical attributes of the storage vessel directly impact the shelf life of the compound. All research environments should utilize clean, chemically inert containers. Glass vials provide the highest level of protection against gas permeability and chemical interaction, though high-density polypropylene tubes serve as a valid alternative. Keep all stored peptides away from automatic frost-free freezers, as their internal defrost cycles create regular temperature swings that compromise peptide longevity.