Gonadorelin

Product Overview

A fundamental standard in neuroendocrine and reproductive physiology research dictates that exploring advanced pituitary signaling molecules demands both uncompromised structural integrity and verification of chemical purity. The Gonadorelin formulation satisfies these rigorous requirements, serving as a highly refined decapeptide engineered for precise laboratory investigation into the hypothalamic-pituitary-gonadal (HPG) axis. Each vial delivers pure Gonadorelin, stabilized as a vacuum freeze-dried (lyophilized) powder with a verified purity profile exceeding 98%.

Gonadorelin is a synthetic peptide structurally identical to endogenous gonadotropin-releasing hormone (GnRH). It is composed of a precise 10-amino acid sequence (H-Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂) with a molecular weight of 1182.31 g/mol and a chemical formula of C₅₅H₇₅N₁₇O₁₃. To optimize its utility in experimental models, its linear structural sequence is meticulously synthesized to preserve the exact conformation required for high-affinity receptor binding, allowing it to interface directly with target systems without triggering non-specific cellular breakdown.

Operating as a primary neuroendocrine signaling agent, Gonadorelin acts as a potent agonist at gonadotropin-releasing hormone receptors (GnRH-R) located on the surface of anterior pituitary gonadotrope cells. The binding interaction activates phospholipase C pathways, triggering an intracellular calcium influx that drives the exocytosis of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Documented research indicates that Gonadorelin's effects depend strictly on exposure kinetics: pulsatile administration stimulates stable gonadotropin synthesis, whereas continuous, sustained exposure downregulates and desensitizes the receptors. This dual dynamic permits the detailed investigation of targeted receptor feedback mechanisms, steroidogenesis cascades, and hormone-dependent cellular pathways within controlled laboratory settings.

Product Specifications

• Form: Lyophilized (vacuum freeze-dried) powder
• Purity: Greater than 98% (verified by HPLC analysis)
• Amino Acid Structure: Decapeptide (10-amino acid GnRH sequence)
• Molecular Weight: 1182.31 g/mol
• Target System: Anterior Pituitary Gonadotrope Receptors (GnRH-R)
• Primary Research Focus: HPG Axis Kinetics, Pulsatile Signaling, and Secondary Steroidogenesis

Container Specifications

The physical attributes of the storage vessel directly impact the shelf life of the compound. All research environments should utilize clean, chemically inert containers. Glass vials provide the highest level of protection against gas permeability and chemical interaction, though high-density polypropylene tubes serve as a valid alternative. Keep all stored peptides away from automatic frost-free freezers, as their internal defrost cycles create regular temperature swings that compromise peptide longevity.