Humanin

Product Overview

A fundamental standard in mitochondrial biology and cytoprotective research dictates that exploring advanced endogenous signaling peptides requires complete structural integrity and verified chemical purity. The Humanin formulation addresses these demanding benchmarks, serving as a highly purified synthetic mitochondrial-derived peptide (MDP) developed for precise in vitro and in vivo laboratory modeling. Each vial provides pure Humanin, stabilized as a vacuum freeze-dried (lyophilized) powder maintaining a verified purity profile of greater than 98%.

Humanin is a 24-amino acid linear polypeptide encoded within the 16S ribosomal RNA gene of the mitochondrial genome. Characterized by the specific primary sequence H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH, it features a molecular weight of 2687.2 g/mol. Meticulously synthesized to preserve its native chemical structure, this compound possesses distinct hydrophobic and hydrophilic domains that allow it to interface dynamically with both cell-surface receptors and intracellular target proteins.

Operating primarily as a potent cytoprotective and anti-apoptotic agent, Humanin exerts its effects through dual localized mechanisms. Extracellularly, it binds with high affinity to membrane-bound receptor complexes, such as the trimeric IL-6 receptor framework (comprising CNTFR, WSX-1, and gp130), to trigger protective STAT3 activation cascades. Intracellularly, it physically interacts with pro-apoptotic proteins like Bax and Bid, effectively preventing their translocation to the outer mitochondrial membrane and suppressing subsequent cytochrome c release. Documented research demonstrates that Humanin actively safeguards neuronal networks against amyloid-beta toxicity, shields cardiovascular tissues from ischemic stress, and supports metabolic homeostasis. These diverse actions allow researchers to investigate cellular survival pathways, mitochondrial signaling dynamics, and age-related degenerative models within controlled laboratory environments.

Product Specifications

• Form: Lyophilized (vacuum freeze-dried) powder
• Purity: Greater than 98% (verified by HPLC analysis)
• Peptide Class: Mitochondrial-Derived Peptide (MDP)
• Amino Acid Sequence: 24-residue linear chain (Met-Ala-Pro... structure)
• Molecular Weight: 2687.2 g/mol
• Primary Research Focus: Cytoprotection, Anti-Apoptotic Signaling, and Mitochondrial Homeostasis

Container Specifications

The physical attributes of the storage vessel directly impact the shelf life of the compound. All research environments should utilize clean, chemically inert containers. Glass vials provide the highest level of protection against gas permeability and chemical interaction, though high-density polypropylene tubes serve as a valid alternative. Keep all stored peptides away from automatic frost-free freezers, as their internal defrost cycles create regular temperature swings that compromise peptide longevity.