LL-37

Product Overview

A fundamental standard in antimicrobial and innate immunity research dictates that exploring advanced host-defense compounds requires complete structural integrity and verified chemical purity. The LL-37 formulation addresses these demanding benchmarks, serving as a highly purified synthetic cathelicidin peptide developed for precise in vitro and in vivo laboratory modeling. Each vial provides pure LL-37, stabilized as a vacuum freeze-dried (lyophilized) powder maintaining a verified purity profile of greater than 98%.

LL-37 is an endogenous 37-amino acid linear peptide derived from the C-terminal end of the human cathelicidin antimicrobial protein hCAP18. Characterized by its specific primary sequence beginning with two leucine residues, this amphipathic alpha-helical molecule possesses unique structural dynamics. Because of its structural geometry, LL-37 can rapidly transition its conformation upon interacting with biological membranes, enabling high biological activity across diverse cellular environments.

Operating primarily as a multifunctional host-defense molecule, LL-37 functions via both direct membrane disruption and complex receptor-mediated signaling pathways. The peptide interacts with anionic cell membranes of target pathogens, inducing transmembrane pore formation and subsequent lysis. Beyond direct antimicrobial actions, it interfaces with specific cell surface receptors such as formyl peptide receptor-like 1 (FPRL1) on immune cells to trigger chemotaxis, modulate cytokine networks, and influence angiogenesis. These diverse mechanisms allow for the precise investigation of innate immune responses, tissue repair dynamics, and cellular stress resistance within controlled laboratory settings.

Product Specifications

• Form: Lyophilized (vacuum freeze-dried) powder
• Purity: Greater than 98% (verified by HPLC analysis)
• Peptide Class: Cathelicidin-derived Antimicrobial Peptide (37-amino acid sequence)
• Molecular Architecture: Amphipathic Alpha-Helix
• Primary Research Focus: Innate Immunomodulation, Wound Healing, and Pathogen Disruption

Container Specifications

The physical attributes of the storage vessel directly impact the shelf life of the compound. All research environments should utilize clean, chemically inert containers. Glass vials provide the highest level of protection against gas permeability and chemical interaction, though high-density polypropylene tubes serve as a valid alternative. Keep all stored peptides away from automatic frost-free freezers, as their internal defrost cycles create regular temperature swings that compromise peptide longevity.